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KMID : 0380020160310040291
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Korean Journal of Biotechnology and Bioengineering
2016 Volume.31 No. 4 p.291 ~ p.299
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Effect of Polyethylene Glycol on Physicochemical Property in Dispersing Film Formulation
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Cho Young-Ho
Lee Jong-Hwa
Lee Gye-Won
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Abstract
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In this study, Indomethacin, the poorly water soluble drug, was selected and prepared dispersing oral disintegrating films according to the molecular weight of polyethylene glycol (PEG) which are sort of dispersing agents. Also the molecular weight and content of PEG were evaluated effect on the degree of dispersion, physical property and dissolution when making oral dispersing film containing indomethacin to find appropriate condition and suggested guidelines of making oral dispersing film. The appropriate dispersing ratio of the amount of surfactants and dispersing agent were 1% and 4%, also the stability dropped in the PEG molecular weight of 4000 or more. Drying time of oral dispersing film was 90oC for 10 minutes to 12 minutes that dispersing film’s property about flexibility, detachability were very good. The oral dispersion film’s content used PEG 400 was 98.6± 0.5% and the most uniform. As the molecular weight of PEG increased, dissolution time also increased. On the basis of evaluation parameter, PEG with 400~600 of molecular weight was selected as good dispersing agent in oral dispersing film. Therefore, it can be suggested guideline of preparation application study in oral dispersing film.
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KEYWORD
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Dispersing oral film, Indomethacin, Flexibility, Polyethylene glycol
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